What casino game has the best odds? Video poker can provide the best odds in a casino, depending on the version of the paytable. However, blackjack is generally regarded as having the best casino odds when using basic strategy. This can help lower the house edge to around 0.50%.

1. Mega Joker  99% RTP. Mega Joker from NetEnt has been around for more than a decade. Though it's a relatively simple game with just three reels and three rows, Mega Joker is a famous and beloved high-volatility slot thanks largely to its eye-popping 99% RTP, bonus Supermeter game, and progressive jackpot.